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目的:为了了解西安地区急性GBV-C/HGV感染者的分子流行病学及临床特征。 方法:连续收集急性病毒性肝炎病例458例,诊断符合上海会议标准。经EHSA检测的67例非甲-戊型肝炎患者经套式PCR方法检测HGVRNA,采用统一《急性病毒性肝炎调查表》,由专人负责进行临床和流行病学调查。所有数据用EPI软件处理。 结果:经ELISA检测的67例非甲-戊型肝炎患者经套式PCR方法检测有17例呈HGVRNA阳性,50为诊断不明患者。通过对17例HGVRNA阳性患者的流行病学分布所进行的分析表明HGV极易感染抵抗力较弱的儿童和老年人,26岁以下占88.23％,与同一人群同年龄乙肝、丙肝和丁肝患者相比,明显增多,经x~2检验有统计学意义(P<0.05)。而当HGV与HCV或HBV同时感染时,致病力增强,可以使各年龄段人群感染。同时我们可以看到HGVRNA阳性患者于冬春季有一明显的发病高峰,尤以冬季为明显。 结论:GBV-C/HGV并不是临床急性肝炎的主要致病因子。HGVRNA阳性患者在暴露因素、流行病学及临床特征等方面具有与其他各型肝炎相同或相似的特点。
Objective: To understand the molecular epidemiology and clinical features of acute GBV-C / HGV infection in Xi’an. Methods: 458 consecutive cases of acute viral hepatitis were collected, and the diagnosis accorded with the standard of Shanghai conference. HGVRNA was detected by nested PCR in 67 non-A-E patients tested by EHSA. A unified “Acute Viral Hepatitis Checklist” was used to conduct clinical and epidemiological investigations by hand. All data is processed using EPI software. Results: 67 cases of non-A-hepatitis E were detected by ELISA in 17 cases of HGV RNA positive by nested PCR, 50 were unknown. Analysis of the epidemiological distribution of 17 HGV RNA-positive patients showed that HGV was highly susceptible to children and the elderly with weaker resistance, accounting for 88.23% under 26 years of age, with the same population of hepatitis B, hepatitis C and hepatitis B patients Compared with the significant increase, by x ~ 2 test was statistically significant (P <0.05). When HGV is infected with HCV or HBV at the same time, the pathogenicity is enhanced, which can infect people of all ages. At the same time, we can see that HGVRNA positive patients have a significant peak in winter and spring, especially in winter. Conclusion: GBV-C / HGV is not the main causative agent of clinical acute hepatitis. Patients with positive HGVRNA have the same or similar characteristics as other types of hepatitis in terms of exposure factors, epidemiology and clinical features.