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目的：探析绝经期抑郁症患者进行盐酸氟西汀与激素补充联合治疗的临床效果分析。方法选取我院2013年12月至2014年12月绝经期抑郁症患者124例，根据随机数字表法分为研究组、对照组，每组62例，研究组进行盐酸氟西汀与激素补充联合治疗，对照组进行激素补充疗法，两组均治疗12周，治疗后比较两组的临床效果；应用SDL自评量表评估两组治疗前后的更年期症状；进行汉密尔顿抑郁量表（HAMD）评估两组治疗前后的抑郁评分。结果研究组治疗后的临床有效率为75.8%显著高于对照组的56.5%，差异有统计学意义（P＜0.05）；研究组治疗4周、治疗8周、治疗12周的更年期症状SDL自评量表评分显著优于对照组，差异有统计学意义（P<0.05）；研究组治疗4周、治疗8周、治疗12周的汉密尔顿抑郁量表（HAMD）评分显著优于对照组，差异有统计学意义（P＜0.05）。结论绝经期抑郁症进行盐酸氟西汀与激素补充联合治疗可显著改善患者的更年期症状，改善患者的抑郁程度，临床效果确切，值得临床推广。“,”Objective:To analyze the clinical effects of Fluoxetine combined with hormone replacement therapy in menopausal depression. Methods:124 patients with menopausal depression treated from December 2013 to December 2014 in our hospital were selected and randomly divided into research group and control group, 62 cases each group. The research group adopted Fluoxetine combined with hormone replacement therapy;the control group adopted hormone replacement therapy. After 12w of treatment, the clinical effects of two groups were compared;the menopausal symptoms based on SDL and depression scores based on HAMD of two groups before and after treatment were evaluated. Results:After treatment, the clinical effective rate of research group (75.8%) was signiifcantly higher than that of control group(56.5%) (P<0.05);after 4w, 8w and 12w of treatment, the score of menopausal symptoms based on SDL of research group was signiifcantly bet er than that of control group (P<0.05);after 4w, 8w and 12w of treatment, the score of HAMD of research group was signiifcantly bet er than that of control group (P<0.05).Conclusion:Fluoxetine combined with hormone replacement therapy has an obvious effect in menopausal depression, can signiifcantly improve the menopausal symptoms and depression. It is worthy of clinical promotion.