论文部分内容阅读
目的探讨光疗及大剂量丙种球蛋白联合茵栀黄治疗新生儿高胆红素血症的效果。方法选取2014年1月-2016年2月在该院治疗的高胆红素血症新生儿84例,随机分为观察组和对照组,每组42例,两组均给予光疗及大剂量丙种球蛋白治疗,观察组加用茵栀黄注射液治疗,观察两组治疗疗效、光疗时间、皮肤黄染消退时间以及生长发育情况等。结果观察组治疗,总有效率为95.24%,疗效优于对照组,差异有统计学意义(P<0.05);两组治疗后胆红素均较治疗前降低,治疗前后差异均有统计学意义(均P<0.05);观察组和对照组治疗后胆红素分别为(97.81±20.43)μmol/L和(128.06±35.22)μmol/L,观察组明显低于对照组治疗后水平,差异有统计学意义(P<0.05);观察组光疗时间和黄疸消退时间分别为(16.20±4.82)h和(4.82±1.43)d,均明显短于对照组的(20.81±9.18)h和(6.26±1.31)h,差异有统计学意义(P<0.05);观察组体质量增长、摄入奶量及大便次数均明显多于对照组,差异均有统计学意义(均P<0.05)。结论光疗及大剂量丙种球蛋白联合茵栀黄治疗新生儿高胆红素血症,其临床疗效好,能有效降低胆红素,促进患儿生长发育。
Objective To investigate the effect of phototherapy and high-dose gamma globulin combined with Yinzhihuang on neonatal hyperbilirubinemia. Methods Eighty-four neonates with hyperbilirubinaemia who were treated in our hospital from January 2014 to February 2016 were randomly divided into observation group and control group, with 42 cases in each group. Both groups were given phototherapy and high dose of C Globulin treatment, the observation group plus Yinzhihuang injection treatment, treatment efficacy, phototherapy time, yellow dying time and growth and development of the two groups were observed. Results The total effective rate was 95.24% in the observation group, the curative effect was better than that in the control group, the difference was statistically significant (P <0.05); bilirubin in both groups was lower than before treatment, the difference was statistically significant (All P <0.05). The bilirubin in the observation group and the control group were (97.81 ± 20.43) μmol / L and (128.06 ± 35.22) μmol / L respectively after treatment, and the observation group was significantly lower than the control group after treatment (16.20 ± 4.82) h and (4.82 ± 1.43) d in the observation group, which were significantly shorter than those in the control group (20.81 ± 9.18) h and (6.26 ± 1.31) h, the difference was statistically significant (P <0.05). The body weight gain, milk intake and stool frequency in the observation group were significantly more than those in the control group (all P <0.05). Conclusion Phototherapy and high-dose gamma globulin combined with Yinzhihuang treatment of neonatal hyperbilirubinemia, its good clinical efficacy, can effectively reduce the bilirubin and promote the growth and development of children.