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目的:在高危型HPV潜伏感染无临床及组织学异常表现时,进行早期干预治疗,从病因学源头阻断宫颈上皮内瘤变(CIN)的发生,并探讨加入中药洗剂“妇安宁”治疗后的效果。方法:选择2011年1月~3月在常熟市中医院妇科就诊的106例高危型HPV-DNA(+)和TCT(-)患者的临床资料,随机将其分为治疗组(56例)和对照组(50例),治疗组采用重组人干扰素α-2b栓联合妇安宁洗剂外用,对照组采用重组人干扰素α-2b栓治疗。结果:治疗组患者转阴53例(94.64%),对照组患者转阴47例(94.0%),两组HPV转阴率比较,差异无统计学意义(P>0.05)。对照组1例发展为CIN,治疗组无CIN发生。第一阶段治疗后,治疗组的HPV转阴率为35.71%,对照组的为28.0%,两组比较,差异无统计学意义(P>0.05)。第二阶段治疗后,治疗组HPV转阴率为61.11%,对照组为44.44%,两组比较,差异无统计学意义(P>0.05)。第三阶段治疗后,治疗组HPV转阴率为35.71%,显著低于对照组(70.0%),两组比较,差异有统计学意义(P<0.05)。第四阶段治疗后,治疗组HPV转阴率为66.67%,对照组HPV转阴率为50.0%,两组比较,差异无统计学意义(P>0.05)。结论:两组的治疗效果无显著差异,但在加入中药洗剂妇安宁治疗后,可缩短高危型HPV的转阴的时间,且可延缓CIN的发生。
OBJECTIVE: To prevent the occurrence of cervical intraepithelial neoplasia (CIN) at the source of etiology by early intervention in high-risk HPV latent infection without clinical and histological abnormalities, After treatment effect. Methods: The clinical data of 106 cases of high-risk HPV-DNA (+) and TCT (-) patients attending gynecology department of Changshu Hospital of Traditional Chinese Medicine from January to March of 2011 were randomly divided into treatment group (56 cases) and Control group (n = 50). The treatment group was treated with recombinant interferon α-2b suppository and Fufang Ning lotion. The control group was treated with recombinant human interferon α-2b suppository. Results: In the treatment group, 53 cases (94.64%) were negative and 47 cases (94.0%) were negative in the control group. There was no significant difference in HPV negative conversion rate between the two groups (P> 0.05). One patient in the control group developed CIN, and no CIN occurred in the treatment group. After the first phase of treatment, the negative rate of HPV in the treatment group was 35.71% and that in the control group was 28.0%. There was no significant difference between the two groups (P> 0.05). After the second phase of treatment, the treatment group, HPV negative conversion rate was 61.11%, 44.44% in the control group, the two groups, the difference was not statistically significant (P> 0.05). After the third phase of treatment, the negative conversion rate of HPV in the treatment group was 35.71%, which was significantly lower than that in the control group (70.0%). There was significant difference between the two groups (P <0.05). After the fourth phase treatment, the HPV negative conversion rate was 66.67% in the treatment group and 50.0% in the control group. There was no significant difference between the two groups (P> 0.05). CONCLUSION: There is no significant difference between the two groups in the treatment effect. However, after the Chinese herbal lotion is used, the time of negative conversion can be shortened and the occurrence of CIN can be delayed.