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目的:探讨手足口病合并脑炎患儿采用喜炎平注射液联合清热解毒合剂治疗的临床效果。方法:将医院收治的52例手足口病合并脑炎患儿按数字表法分为对照组和观察组,每组26例患儿。对照组患儿采用常规抗病毒治疗,观察组患儿则在对照组治疗基础上采用喜炎平注射液联合清热解毒合剂治疗,对比两组患儿的治疗效果、治疗起效时间及治疗前后的血清学指标变化情况。结果:观察组患儿治疗的临床总有效率(88.47%)和对照组临床总有效率(65.38%)相比明显提高;观察组患儿热程(3.41±1.62)d、头痛缓解时间(2.96±1.31)d、意识恢复时间(2.16±1.02)d和对照组患儿热程(5.54±1.29)d、头痛缓解时间(4.12±1.28)d、意识恢复时间(3.59±1.01)d相比明显缩短;观察组患儿治疗7 d后血清ALP(8.92±0.33)1000U/L、血清PA(228.31±35.64)mg/L明显高于对照组血清ALP(7.08±0.13)1000U/L、血清PA(172.47±25.74)mg/L,差异具有统计学意义(P<0.05)。结论:手足口病合并脑炎患儿采用喜炎平注射液联合清热解毒合剂治疗效果显著,不仅起效快,可明显缓解患儿发热、流涎等症状,而且能有效改善患儿血清学指标,加快患儿康复。
Objective: To investigate the clinical effect of Xiyanping injection combined with Qingrejiedu Mixture in children with hand-foot-mouth disease combined with encephalitis. Methods: 52 cases of hand, foot and mouth disease with encephalitis admitted to the hospital were divided into control group and observation group according to digital table method, with 26 cases in each group. The control group of children with conventional antiviral therapy, the observation group of children in the control group based on the treatment of Xiyanping injection combined with Qingrejiedu mixture treatment, the two groups were compared with the treatment effect, treatment onset time and before and after treatment Changes in serological indicators. Results: The total effective rate (88.47%) in the observation group was significantly higher than that in the control group (65.38%). The fever in the observation group (3.41 ± 1.62) d and the headache relief time (2.96 ± 1.31) d, recovery time (2.16 ± 1.02) d and control group (5.54 ± 1.29) d, headache relief time (4.12 ± 1.28) d and consciousness recovery time (3.59 ± 1.01) d (P <0.01). After treatment for 7 days, the serum ALP level in the observation group was (8.92 ± 0.33) 1000U / L and that in the serum PA group was 228.31 ± 35.64 mg / L, which was significantly higher than that in the control group 172.47 ± 25.74) mg / L, the difference was statistically significant (P <0.05). Conclusion: Children with hand, foot and mouth disease with encephalitis using Xiyanping injection combined with Qingrejiedu mixture treatment effect is not only fast onset, can significantly alleviate fever, salivation and other symptoms in children, but also can effectively improve children with serum markers, Accelerate the recovery of children.