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Objective: To explore changes of neural stem cells (NSCs) following intracerebral hemorrhage (ICH) and the effect of Nao Yi-an granule (脑溢安颗粒, NYA) on them, and furthermore, to explore NYA’s therapeutic mechanism Methods: Sixty rats were randomly divided into three groups, the sham operation control group, the ICH group and the NYA-treated group. Except those in the sham operation control group, all other rats were replicated to ICH models by stereotactical injection of collagenase type Ⅶ into their globus pallidus. After modeling, the rats in the NYA-treated group were administered with NYA at the dosage of 4. 92 g·kg-1·d-1 by gastrogavage, while those in the other two groups, 4 ml distilled water were given instead. The behavioral test was used to evaluate neurological deficit and immunohistochemical method was used to detect Nestin expression, the special marker for neural stem cells. Results: The ICH animals showed notable placing deficit in forlimbs from day 1 to day 28 after modeling. The d
Objective: To explore changes of neural stem cells (NSCs) following intracerebral hemorrhage (ICH) and the effect of Nao Yi-an granule (脑脑安粒, NYA) on them, and furthermore, to explore NYA’s therapeutic mechanism Methods: Sixty rats Were randomly divided into three groups, the sham operation control group, the ICH group and the NYA-treated group. Except those in the sham operation control group, all other rats were replicated to ICH models by stereotactical injection of collagenase type VII into their globus Pallidus. After modeling, the rats in the NYA-treated group were administered with NYA at the dosage of 4. 92 g·kg-1·d-1 by gastrogavage, while those in the other two groups, 4 ml distilled water were Instead. The behavioral test was used to evaluate neurological deficit and immunohistochemical method was used to detect Nestin expression, the special marker for neural stem cells. Results: The ICH animals showed not possible delivery deficit in forlimbs from day 1 to day 28 after modeling. The d