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Resveratrol (3, 5, 4’-trihydroxystilbene) (RV) is a constituent of grape seeds with anti-inflammatory andanti-oxidant activities. In this study, we examined the capacity of RV to modulate the function of Gprotein-coupled chemoattractant receptors, which play important roles in inflammation and immune responses.RV, over a non-cytotoxic concentration range, inhibited chemotactic and calcium mobilization responses ofphagocytic cells to selected chemoattractants. At low micromolar concentrations,RV potently reducedsuperoxide anion production by phagocytic leukocytes in response to the bacterial chemotactic peptide fMLF, ahigh affinity ligand for formylpeptide receptor FPR, and Ap.4z, an Alzheimer’s disease-associated peptide and aligand for the FPR variant FPRL1. In addition, RV reduced phosphorylation of extracellular signal-regulatedkinase (ERK1/2) and the activation of nuclear factor NF-KB induced by formylpeptide receptor agonists. Theseresults suggest that the inhibition of the function of chemoattractant receptors may contribute to theanti-inflammatory properties of RV Thus, RV may be therapeutically promising for diseases in which activationof formylpeptide receptors contributes to the pathogenic processes. Cellular&Molecular Immunology. 2004;1(1):50-56.
In this study, we examined the capacity of RV to modulate the function of Gprotein-coupled chemoattractant receptors, Which play important roles in inflammation and immune responses.RV, over a non-cytotoxic concentration range, inhibited chemotactic and calcium mobilization responses of phagocytic cells to selected chemoattractants. At low micromolar concentrations,RV potently reducedsuperoxide anion production by phagocytic leukocytes in response to the bacterial Chemotactic peptide fMLF, ahigh affinity ligand for formylpeptide receptor FPR, and Ap.4z, an Alzheimer’s disease-associated peptide and aligand for the FPR variant FPRL1. In addition, RV reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and the activation Of nuclear factor NF-KB induced by formyl peptide receptor agonists. Theseresults suggest that the inhibition of the functi On of chemoattractant receptors may contribute to the anti-inflammatory properties of RV Thus, RV may be therapeutically promising for diseases in which activation of formylpeptide receptors contributes to the pathogenic processes. Cellular & Molecular Immunology. 2004;1(1):50-56.