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脂蛋白和血脂是冠心病(CAD)的重要的危险因子,然而大约30％-40％的CAD病人却不存在这些 因素。作者检测了多种非脂类指标,以评价其在CAD发展过程中所起的作用。初步研究表明,某些CAD患者的血清胆红素降低,同时有些肝脏内酶的活性增加。为了进一步弄清胆红素与CAD是否有关,作者选择了877名做冠脉造影的美国空军飞行员(男性)作为实验对象。此项研究中,将血清胆红素和肝内酶(如:ALT、AST、AP、LDH等)与数种已明确为CAD危险因子的指标作了比较,如TC、HDL-C、TG、平均每日吸烟数目、收缩压、空腹血糖和
Lipoproteins and lipids are important risk factors for coronary heart disease (CAD), yet about 30% -40% of CAD patients do not have these factors. The authors tested a variety of non-lipid indicators to assess their role in the development of CAD. Preliminary studies have shown that some patients with CAD serum bilirubin decreased, while some liver enzyme activity increased. To further clarify whether bilirubin is associated with CAD, the authors selected 877 US Air Force pilots (men) who underwent coronary angiography as their subjects. In this study, serum bilirubin and intrahepatic enzymes (such as ALT, AST, AP, LDH, etc.) were compared with several indicators that have been identified as CAD risk factors such as TC, HDL-C, TG, Average number of daily smokers, systolic blood pressure, fasting blood glucose, and