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CD34/CD56是至今尚未研究的标记复合物。N-CAM是神经细胞粘附分子,有CD56抗原,正常时其出现于外周血中具有自然杀伤细胞活性的淋巴细胞上。已知一些急性髓细胞白血病细胞和未成熟白血病细胞系有CD56抗原,未发现CD34正常造血祖细胞有CD56抗原。 作者用免疫荧光双标记CD34和CD56,经流式细胞仪检测急性髓细胞白血病(AML)的微量残留病(MRD),发现此双标记表达于约20％的儿童AML白血病细胞,且与伴t(8;21)(q22;q22)核型
CD34 / CD56 is a marker complex that has not been studied so far. N-CAM is a neural cell adhesion molecule that has a CD56 antigen that normally appears on lymphocytes that have natural killer cell activity in the peripheral blood. It is known that some acute myeloid leukemia cells and immature leukemia cell lines have CD56 antigens and no CD56 antigens have been found on normal CD34 normal hematopoietic progenitor cells. The authors double-labeled immunofluorescence CD34 and CD56, flow cytometry of acute myeloid leukemia (AML) trace residual disease (MRD) and found that the double marker was expressed in about 20% of childhood AML leukemia cells, and with t (8; 21) (q22; q22) karyotype