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目的:评价n ANRIL基因rs4977574、rs1537378位点多态性与缺血性脑卒中发病的关联。n 方法:应用计算机检索PubMed、Embase、The Cochrane Library、中国知网、万方和维普数据库，收集其中自建库至2020年9月公开发表的关于n ANRIL基因rs4977574、rs1537378位点多态性与缺血性脑卒中发病关联的随机对照试验(RCT)文献，根据纳入、排除标准对文献进行筛选并提取其中的资料，采用Stata15.1软件对文献资料进行Meta分析。n 结果:关于n ANRIL基因rs4977574位点多态性与缺血性脑卒中发病的关联，共纳入7篇文献，包括病例组12 553例、对照组15 547例；关于n ANRIL基因rs1537378位点多态性与缺血性脑卒中发病的关联，共纳入6篇文献，包括病例组6166例、对照组6129例。Meta分析显示：n ANRIL基因rs4977574位点多态性与缺血性脑卒中发病风险增加在等位基因模型(G n vs. A：n OR=1.110，n 95%CI：1.020~1.210，n P=0.010)、显性模型[(GG+GA) n vs. AA：n OR=1.170，n 95%CI：1.070~1.280，n P=0.001]、隐性模型[GG n vs. (GA+AA)：n OR=1.160，n 95%CI：1.050~1.280，n P=0.020]、纯合子模型(GG n vs. AA：n OR=1.260，n 95%CI：1.130~1.420，n P=0.000)及杂合子模型(GA n vs. AA：n OR=1.130，n 95%CI：1.030~1.240，n P=0.010)下均具有关联；n ANRIL基因rs1537378位点多态性与缺血性脑卒中发病风险减小在等位基因模型(T n vs. C：n OR=0.800，n 95%CI：0.700~0.920，n P=0.001)、显性模型[(TT+TC) n vs. CC：n OR=0.790，n 95%CI：0.680~0.920，n P=0.002]、隐性模型[TT n vs. (TC+CC)：n OR=0.830，n 95%CI：0.740~0.930，n P=0.001]、纯合子模型(TT n vs. CC：n OR=0.780，n 95%CI：0.690~0.880，n P=0.000)及杂合子模型(TC n vs.CC：n OR=0.870，n 95%CI：0.810~0.940，n P=0.001)下均具有关联。n 结论:ANRIL基因rs4977574、rs1537378位点多态性与缺血性脑卒中发病均存在关联，其中rs4977574位点的等位基因G会显著增加罹患缺血性脑卒中的风险，rs1537378位点的等位基因T会降低缺血性脑卒中的发病风险。n “,”Objective:To study the associations between single-nucleotide polymorphisms (SNPs) of rs4977574/rs1537378 in n ANRIL gene and risk of ischemic stroke.n Methods:PubMed, Embase, The Cochrane Library, and CNKI, Wanfang, and VIP Data were searched from inception to September 2020 to collect literatures about randomized controlled trials on associations between SNPs of rs4977574/rs1537378 in n ANRIL gene and risk of ischemic stroke. According to inclusion and exclusion criteria, the literatures were selected and the data were extracted; Stata15.1 software was used for Meta analysis of the literatures.n Results:About the associations between rs4977574 polymorphism of n ANRIL gene and risk of ischemic stroke, a total of 7 articles were chosen, including 12 553 patients in the case group and 15 547 patients in the control group; about the associations between rs1537378 polymorphism of n ANRIL gene and risk of ischemic stroke, a total of 6 articles were chosen, including 6166 patients in case group and 6129 patients in control group. The results of Meta analysis indicated that rs4977574 polymorphism had a significant association with ischemic stroke susceptibility under 5 genetic models: allele model [G n vs. A]: n OR=1.110, n 95%CI: 1.020-1.210, n P=0.010; dominance model ([GG+GA] vn s. AA): n OR=1.170, n 95%CI: 1.070-1.280, n P=0.001; recessive model (GG n vs. [GA+AA]): n OR=1.160, n 95%CI: 1.050-1.280, n P=0.020; homozygote model (GG n vs. AA): n OR=1.260, n 95%CI: 1.130-1.420, n P=0.000; heterozygote model (GA n vs. AA): n OR=1.130, n 95%CI: 1.030-1.240, n P=0.010. The rs1537378 polymorphism was associated with reduced risk of ischemic stroke under 5 genetic models: allele model (T n vs. C): n OR=0.800, n 95%CI: 0.700-0.920, n P=0.001; dominance model ([TT+TC] n vs. CC): n OR=0.790, n 95%CI: 0.680-0.920, n P=0.002; recessive model (TT n vs. [TC+CC]): n OR=0.830, n 95%CI: 0.740-0.930, n P=0.001; homozygote model (TT n vs. CC): n OR=0.780, n 95%CI: 0.690-0.880, n P=0.000; heterozygote model (TC n vs. CC): n OR=0.870, n 95%CI: 0.810-0.940, n P=0.001.n Conclusions:The rs4977574 polymorphism in n ANRIL gene is a susceptibility factor for ischemic stroke, and allele G of this locus can significantly increase the risk of ischemic stroke. The rs1537378 polymorphism in n ANRIL gene is a protective factor for ischemic stroke, and carrying this allele T can reduce the risk of ischemic stroke.n