Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis

• 作 者: Kelley M Argraves Brent A Wilk
• 机 构: DepartmentofRegenerativeMedicineandCellBiology
• 出 处: 世界生物化学杂志：英文版（电子版）
• 发表日期: 2010年10期
• 关键词: Sphingosine-1-phosphate VASCULOGENESIS ANGIOGENESIS G-protein-coupled receptors
• 基金项目: Supported by Grants from the United States Public Health Service/National Institutes of Health, No. HL080404, HL094883 (Argraves KM) and HL061873, HL095067 (Argraves WS),NIH Training Grant to Improve

Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive network of signaling cascades downstrea