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目的通过检测不稳定性心绞痛(UAP)患者血清中1型辅助性T细胞(Thl)(包括IL-2、IFN-γ)和2型辅助性T细胞(Th2)((包括IL-10)细胞因子的变化,探讨其在UAP发病过程中的作用及对近期预后的判断价值。方法选取UAP患者40例(UAP组)及稳定性心绞痛(SAP)患者38例(SAP组),同时选取健康体检者24例(对照组),测定各组血清中的IFN-γ、IL-2和IL-10水平,并观察UAP患者3个月内不良心脏事件发生率。结果 UAP组血清中IFN-γ、IL-2水平明显高于对照组和SAP组(P均<0.05),而IL-10水平明显低于对照组和SAP组(P均<0.05)。UAP患者中,有心脏事件患者血清IFN-γ、IL-2水平明显高于无心脏事件患者(P均<0.05),IL-10水平明显低于无心脏事件患者(P均<0.05)。结论外周血中Thl和Th2细胞因子水平的变化可能与冠状动脉病变不稳定性斑块的存在有关,可反映冠心病患者临床病情,对判断UAP患者近期预后有较好的预测价值。
Objective To detect the levels of Th1 (including IL-2, IFN-γ) and T helper type 2 (Th2) (including IL-10) cells in serum of patients with unstable angina pectoris (UAP) And explore its role in the pathogenesis of UAP and the value of its prognosis.Methods Thirty-eight UAP patients and 38 SAP patients (SAP group) were enrolled in this study.At the same time, healthy volunteers 24 cases (control group), the levels of IFN-γ, IL-2 and IL-10 in serum of each group were measured and the incidence of adverse cardiac events within 3 months of UAP were observed.Results Serum levels of IFN-γ, (P <0.05), while the level of IL-10 was significantly lower than that of the control group and the SAP group (all P <0.05) .In patients with UAP, the serum level of IFN- The levels of IL-2 and IL-2 were significantly higher than those without cardiac events (all P <0.05), and the levels of IL-10 were significantly lower than those without cardiac events (all P <0.05) .Conclusion The changes of Th1 and Th2 cytokines in peripheral blood May be related to the presence of unstable plaque in coronary artery disease, which can reflect the clinical status of patients with coronary heart disease, which has a good predictive value in judging the short-term prognosis of patients with UAP.