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AIM:To investigate the effect of N-acetyl cysteine (NAC)on acute viral hepatitis (AVH).METHODS:We administered 200 mg oral NAC three timesdaily (600 mg/day) to the study group and placebo capsulesto the control group.All patients were hospitalized anddiagnosed as AVH.Blood total and direct bilirubin,ALT,AST,alkaline phosphatese,albumin and globulin levels of eachpatient were measured twice weekly until total bilirubin leveldropped under 2 mg/dl,ALT level under 100 U/L,follow upwas continued and then the patients were discharged.RESULTS:A total of 41(13 female and 28 male) AVH patientswere included in our study.The period for normalization ofALT and total bilirubin in the study group was 19.7±6.9 daysand 13.7±8.5 days respectively.In the control group it was20.4±6.5 days and 16.9±7.8 days respectively (P>0.05).CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.
AIM: To investigate the effect of N-acetyl cysteine (NAC) on acute viral hepatitis (AVH). METHODS: We administered 200 mg oral NAC three times daily (600 mg / day) to the study group and placebo capsulesto the control group. All patients were hospitalized and diagosed as AVH. Blood total and direct bilirubin, ALT, AST, alkaline phosphatese, albumin and globulin levels of eachpatient were measured twice weekly until total bilirubin leveldropped under 2 mg / dl, ALT level under 100 U / L, follow upwas continued and then the patients were discharged .RESULTS: A total of 41 (13 female and 28 male) AVH patients were included in our study. The period for normalization ofALT and total bilirubin in the study group was 19.7 ± 6.9 days and 13.7 ± 8.5 days .In the control group it was 20.4 ± 6.5 days and 16.9 ± 7.8 days respectively (P> 0.05) .CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.