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AIM:To study the protective effects of tumor necrosis factor α(TNFα)antibody on pancreatic encephalopathy in rats.METHODS:One hundred and twenty SD rats were randomlydivided into normal control group,acute necrotizingpancreatitis group and TNFα antibody treated group.Acutehemorrhage necrotizing pancreatitis model in rats wasinduced by retrograde injection of 50g/L sodium taurocholateinto the pancreatobiliary duct.Serum TNFα was detectedand animals were killed 12 h after drug administration.Changes in content of brain water,MDA and SOD as wellas leucocyte adhesion of brain microvessels were measured.RESULTS:In TNFα antibody treated group,serum TNFαlevel was decreased.Content of brain water,MDA and SODas well as leucocyte adhesion were decreased significantlyin comparison with those of acute necrotizing pancreatitisgroup (P<0.05).CONCLUSION:TNFα antibody can alleviate the brain damageof rats with acute hemorrhage necrotizing pancreatitis.
AIM: To study the protective effects of tumor necrosis factor α (TNFα) antibody on pancreatic encephalopathy in rats. METHODS: One hundred and twenty SD rats were randomly divided into normal control group, acute necrotizing pancreatitis group and TNFα antibody treated group. Acutehemorrhage necrotizing pancreatitis model in rats was induced by retrograde injection of 50 g / L sodium taurocholateinto the pancreatobiliary duct. Serum TNFα was detected and animals were killed 12 h after drug administration. Cells in content of brain water, MDA and SOD as wellas leucocyte adhesion of brain microvessels were measured .RESULTS : TNFαlevel was decreased.Content of brain water, MDA and SODas well as leucocyte adhesion were decreased significantlyin comparison with those of acute necrotizing pancreatitisgroup (P <0.05) .CONCLUSION: TNFα antibody could alleviate the brain damage of rats with acute hemorrhage necrotizing pancreatitis