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目的:探讨多发性肌炎(PM)患者肌肉炎性组织中是否存在Th17细胞及数量多少。方法:临床和病理诊断确诊的多发性肌炎患者16例;对照组来自非炎性肌病患者6例。应用免疫荧光组织化学方法检测Th17淋巴细胞的定位及数量。结果:与非肌炎患者比较,免疫荧光组织化学检测到肌炎患者肌肉组织中IL-17表达阳性,主要分布在细胞内,且细胞数量的多少与炎症的严重程度成正相关。结论:Th17细胞有可能参与了多发性肌炎的发病过程。
Objective: To investigate the presence and quantity of Th17 cells in muscle inflammatory tissues of patients with polymyositis (PM). Methods: 16 cases of polymyositis were diagnosed clinically and pathologically. The control group consisted of 6 cases of non-inflammatory myopathies. Immunofluorescence histochemistry was used to detect the location and number of Th17 lymphocytes. Results: Compared with non-myositis patients, the expression of IL-17 in myositis was detected by immunofluorescence histochemistry. The positive expression of IL-17 was mainly located in the cells, and the number of cells was positively correlated with the severity of inflammation. Conclusion: Th17 cells may be involved in the pathogenesis of polymyositis.