论文部分内容阅读
目的总结进展期胃癌术前区域动脉灌注化疗的研究进展。方法对有关进展期胃癌术前区域动脉灌注化疗研究进展的文献进行综述。结果进展期胃癌术前区域动脉灌注化疗可显著降低肿瘤分期,提高R0切除率,提高远期生存率;可有效提高肿瘤及门静脉的药物浓度,既可直接杀伤、破坏癌细胞,还可有效防治肝及淋巴结转移,并可减少毒副作用;动脉灌注化疗短时间内就可导致癌细胞核发生固缩和碎裂;进展期胃癌术前区域动脉灌注化疗时间一般为4~9周,然后根据疗效评价结果进一步决定是否行手术治疗。结论进展期胃癌术前区域动脉灌注化疗理论上较静脉全身化疗更有优势,进一步多中心、大型的临床试验的深入研究可能会为其开辟更为广阔的应用前景。
Objective To summarize the research progress of preoperative regional arterial infusion chemotherapy for advanced gastric cancer. Methods The literature review on the progress of arterial infusion chemotherapy in advanced gastric cancer patients was reviewed. Results The preoperative regional arterial infusion chemotherapy for advanced gastric cancer could significantly reduce the tumor staging, improve the R0 resection rate and improve the long-term survival rate. It can effectively increase the concentration of drugs in the tumor and portal vein, and can kill and destroy cancer cells as well as effectively prevent and treat Liver and lymph node metastasis, and reduce side effects; arterial infusion chemotherapy can cause short-term nuclear condensation and fragmentation of cancer cells; advanced gastric cancer preoperative regional arterial infusion chemotherapy time is generally 4 to 9 weeks, and then according to the evaluation of the efficacy The result further decided whether to undergo surgery. Conclusions Arterial infusion chemotherapy in advanced gastric cancer is more advantageous than intravenous systemic chemotherapy in advanced gastric cancer. Further study on multicenter and large-scale clinical trials may open up broader prospects for its application.