论文部分内容阅读
目的:探讨妊娠合并重型肝炎患者入院时的肝功能及凝血功能指标在预后预测中的作用。方法:回顾分析40例在我院住院治疗的妊娠合并重型肝炎患者的临床资料,其中存活组23例,死亡组17例,分析2组患者入院时肝功能指标及凝血功能指标与预后的关系。结果:存活组与死亡组入院时在总蛋白(TP)、白蛋白(ALB)、血清总胆固醇(CHOL)、凝血酶原时间(PT)及凝血酶原活动度(PTA)之间的差异显著。而谷草转氨酶(AST)、谷丙转氨酶(ALT)、谷草转氨酶/谷丙转氨酶比值(AST/ALT)、总胆红素(TBIL)、直接胆红素(DBIL)、直接胆红素/总胆红素比值(DBIL/TBIL)、总胆醇(TBA)、球蛋白(GLB)、白蛋白/球蛋白比值(A/G)两组间的差异无显著。TP<48g/L、ALB<22g/L、CHOL<2.0mmol/L或PTA<30%,均提示预后不良。结论:入院时的TP、ALB、CHOL、PT、PTA等指标与妊娠合并重型肝炎的预后密切相关,预测预后的指标主要是与肝脏合成功能和凝血功能有关。早期识别、及时转运、集中救治,是妊娠合并重型肝炎成功救治的重要条件之一。
Objective: To investigate the role of hepatic function and coagulation parameters in predicting the prognosis of patients with severe hepatitis during pregnancy. Methods: A retrospective analysis of 40 cases of hospitalized patients with pregnancy in our hospital with severe hepatitis clinical data, including 23 cases of survival and death in 17 cases, analysis of two groups of patients on admission liver function and coagulation function index and prognosis. Results: The differences of total protein (TP), albumin (ALB), total cholesterol (CHOL), prothrombin time (PT) and prothrombin activity (PTA) between survival group and death group were significant . While AST, ALT, AST / ALT, TBIL, DBIL, direct bilirubin / total gallbladder There was no significant difference between the two groups in DBIL / TBIL, TBA, GLB and A / G. TP <48g / L, ALB <22g / L, CHOL <2.0mmol / L or PTA <30%, all suggest poor prognosis. Conclusion: The indexes of TP, ALB, CHOL, PT, PTA on admission are closely related to the prognosis of severe hepatitis during pregnancy. The prognostic indicators are mainly related to hepatic synthesis and coagulation. Early identification, timely transport, focus on treatment, pregnancy is one of the important conditions for successful treatment of severe hepatitis.