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目的:探讨中西医结合治疗缺血性脑卒中患者临床疗效观察及对血脂和炎症因子水平的影响。方法:将260例患者按照随机数字表法随机分为两组,分别为对照组(n=130)和治疗组(n=130)。对照组采用西药治疗,治疗组在对照组基础上结合中药汤剂治疗。两组疗程均为3个月。对比分析两组疗程结束后疗效,治疗前和治疗4周后神经功能缺损评分、血脂水平、血清炎症因子变化,及治疗期间不良反应发生情况。结果:治疗组总有效率(87.69%)显著高于对照组(73.85%)(P<0.05);两组神经功能缺损评分治疗后较治疗前显著降低(P<0.05);治疗组神经功能缺损评分治疗后显著低于对照组(P<0.05);两组TG、TC、LDL-C治疗4周后较治疗前显著降低(P<0.05),而HDL-C较治疗前显著增加(P<0.05);治疗组TG、TC、LDL-C治疗4周后显著低于对照组(P<0.05),而HDL-C显著高于对照组(P<0.05);两组hs-CRP、IL-8、TNF-α治疗4周后均较治疗前显著降低(P<0.05);治疗组hs-CRP、IL-8、TNF-α治疗4周后显著低于对照组,且具有统计学差异(P<0.05);治疗期间两组均未见明显不良反应。结论:中西医结合治疗缺血性脑卒中患者临床疗效显著,可明显改善患者血脂水平,降低炎症反应,具有重要研究价值。
Objective: To investigate the clinical efficacy of traditional Chinese and western medicine in the treatment of patients with ischemic stroke and its effects on serum lipids and inflammatory cytokines. Methods: 260 patients were randomly divided into two groups according to random number table: control group (n = 130) and treatment group (n = 130). The control group was treated with western medicine, and the treatment group was treated with Chinese medicine decoction on the basis of the control group. Two groups of treatment are 3 months. The curative effect of the two groups after the end of treatment was compared and analyzed. The scores of neurological deficits, blood lipid levels, serum inflammatory factors before and 4 weeks after treatment were compared between the two groups and the incidence of adverse reactions during the treatment. Results: The total effective rate (87.69%) in the treatment group was significantly higher than that in the control group (73.85%) (P <0.05). The neurological deficit scores of the two groups were significantly lower than those before treatment (P <0.05) The levels of TG, TC and LDL-C in the two groups were significantly lower than those before treatment (P <0.05), but the levels of HDL-C in the two groups were significantly increased after treatment (P < 0.05). The levels of hs-CRP, IL-6 in the treatment group were significantly lower than those in the control group (P <0.05), while the levels of HDL-C in the treatment group were significantly higher than those in the control group 8 and TNF-α after 4 weeks of treatment were significantly lower than those before treatment (P <0.05). The levels of hs-CRP, IL-8 and TNF-α in the treatment group were significantly lower than those in the control group after 4 weeks of treatment 0.05). There was no obvious adverse reaction in both groups during the treatment. Conclusion: Integrative medicine treatment of ischemic stroke patients with significant clinical efficacy, can significantly improve blood lipid levels, reduce the inflammatory response, has important research value.