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  5. Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor

Study on the drug resistance and the binding mode of HIV-1 integrase with LCA inhibitor

来源 :中国科学：化学英文版 | 被引量 : 0次 | 上传用户：wdyan297
【摘 要】
：
Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the lifecycle of this virus and also an important target for the study of a
【作 者】
：
HU JianPing CHANG Shan CHEN We 
【机 构】
：
DepartmentofChemistry&,LifeSciences
【出 处】
：
中国科学：化学英文版
【发表日期】
：
2007年5期
【关键词】
：
molecular docking MD simulation HIV-1 IN DRUG design molecular docking MD sim 
【基金项目】
：
Supported by the National Natural Science Foundation of China (Grant Nos. 30500429 and 30670497) and Beijing Natural Science Foundation (Grant No. S072002)
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Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the lifecycle of this virus and also an important target for the study of anti-HIV drugs. The binding mode of the wild type IN core domain and its G140S mutant with L-Chi
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