The selective recognition of mismatched d(GCGAGC)2 by the cobalt(III) complex

• 作 者: CHEN Huili YANG Pin
• 机 构: KeyLaboratoryofChemicalBiologyandMolecularEngineeringofMinistryofEducation
• 出 处: 中国科学：化学英文版
• 发表日期: 2005年1期
• 关键词: COBALT complex mismatched DNA mispairing recognition. cobalt complex mismatch
• 基金项目: 国家自然科学基金，山西省自然科学基金

We studied the binding of [Co(phen)2(HPIP)]Cl3 to mismatched d(GCGAGC)2 containing two sheared G:A mispairs by NMR. The result shows that the complex was intercalated into G:A region from the minor groove and extended to the major groove, and could select