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异搏停是一种钙通道阻滞剂,可治疗折返性室上性心动过速,包括窦房折返性心动过速,房室结折返性心动过速和涉及异常房室旁道的房室反复性心动过速(AVRT)。异搏停抑制这些折返性室上性心动过速的机理被归因于它对窦房结和房室结的抑制作用。有几篇研究已显示异搏停对异常房室旁道的电生理特性无抑制作用,AVRT时异搏停引起传导阻滞的部位在房室结内。但在过去三年中,我们观察到异搏停可通过在异常房室旁道中引起传导阻滞而终止AVRT。本文探讨此作用的电生理机理。
Verapamil is a calcium channel blocker for the treatment of reentrant supraventricular tachycardia, including sinoatrial reentrant tachycardia, atrioventricular nodal reentrant tachycardia, and atrioventricular abnormalities involving the atrioventricular compartment Recurrent tachycardia (AVRT). The mechanism by which verapamil inhibits these reentrant supraventricular tachycardias is attributed to its inhibitory effect on the sinus node and atrioventricular node. Several studies have shown that verapamil has no inhibitory effect on the electrophysiological properties of the abnormal atrioventricular bypass. Verapamil causes signs of block in the atrioventricular node during AVRT. However, in the past three years, we have observed that Verapamil terminates AVRT by causing conduction block in the abnormal accessory pathway. This article explores the role of the electrophysiological mechanism.