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脾功能减退(hyposplenism)一词系Eppinger于1913年提出,原指脾切除后状态,也可用以包括获得性脾萎缩引起的脾功能缺陷。长期以来,脾功能减退曾被认为无临床意义。由于若干病例发生暴发性感染,现已普遍认识到该病具有潜在致死性。许多肠病可伴有脾功能减退,故了解其发生率、形成机制、免疫异常及预防措施具有重要意义。肠病时脾功能减退的发生率非脾切除引起的脾功能损害可见于下列肠病:乳糜泻、溃疡性结肠炎、克隆氏病、疱疹性皮炎、热带性口炎性腹泻、肠原性脂代谢障碍、慢
The term hyposplenism, proposed by Eppinger in 1913, originally referred to as post-splenic status, may also be used to include splenic dysfunction caused by acquired splenomegaly. For a long time, spleen dysfunction has been considered as clinically significant. Due to an outbreak of infection in a number of cases, it is now widely recognized that the disease is potentially fatal. Many bowel diseases can be accompanied by spleen dysfunction, so to understand its incidence, formation mechanism, immune abnormalities and preventive measures of great significance. The incidence of splenic dysfunction in bowel disease The non-splenectomy-induced impairment of spleen function can be seen in the following enteric diseases: celiac disease, ulcerative colitis, Crohn’s disease, herpes dermatitis, tropical stomatitis, enteric lipids Metabolic disorders, slow