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自1918年第一个抗血吸虫药物——吐酒石用于血吸虫病治疗后,至目前止世界上已过筛了30万种化合物来寻找较理想药物以替代锑剂。但最近10年内才取得较大进展。1978年底世界卫生组织血吸虫病专家委员会推荐吡喹酮与硝硫氰胺二种化合物为发展阶段中最有前途的药物,在国内目前已广泛
Since the first anti-schistosome drug - tartar in 1918 for the treatment of schistosomiasis, 300,000 compounds have been screened so far in the world to find more desirable drugs to replace antimony agents. However, great progress has been made in the last 10 years. The end of 1978 the WHO expert committee of schistosomiasis recommend praziquantel and nitrofurazone two compounds for the development of the most promising drug in the country has been widely