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休克的发病机理至今尚末完全明确,尤其是“不可逆性休克”的机理还很不清楚,死亡率仍然很高。阐明“不可逆性休克”的发生机理,具有重要的临床实践意义。肠道因素在“不可逆性休克”中的作用,普遍地引起了人们的注意。至于肠道通过什么因素促使“不可逆性休克”发生,各家说法很不一致。Fine 等人特别强调肠源性内毒素的作用。但Nagler 等发现,在肠道缺血性休克的动物中有相当一部分查不出内毒素类物质。而且肠道完全无菌的动物也能产生“不可逆性休克”。另有作者主张局部肠缺血反射性引起交感活性增强,血儿茶酚胺急剧升高所致。此外,尚有人提出5—羟色胺、组织胺等
The pathogenesis of shock has not yet completely clear, especially the mechanism of “irreversible shock” is still not clear, the mortality rate is still high. To clarify the “irreversible shock” mechanism of occurrence, has important clinical practice. Intestinal factors in the “irreversible shock” in the role, generally attracted the attention of people. As for what factors to promote the intestine “irreversible shock” occurred, the argument is very inconsistent. Fine et al emphasize the role of enterogenous endotoxins. However, Nagler et al found that a significant proportion of animals with intestinal ischemic shock did not detect endotoxin. And completely gut-free animals also produce “irreversible shock.” Another advocate of local intestinal reflex reflex induced sympathetic activity increased, a sharp increase in blood catecholamines. In addition, some people have proposed serotonin, histamine and so on