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AIM: To study the activity of gemcitabine and cisplatin in a cohort of patients with inoperable or metastatic cholangiocarcinoma. METHODS: Chemotherapy-naive patients with pathologically proven cholangiocarcinoma,receiving treatment that consisted of gemcitabine at 1250 mg/m2 in a 30-min infusion on d 1 and 8,and cisplatin at 75 mg/m2 at every 21-d cycle,were retrospectively analyzed. RESULTS: From June 2003 to December 2005,42 patients were evaluated. Twelve patients (28%) had unresectable disease and 30 (72%) had metastatic disease. There were 28 males and 14 females with a median age of 51 years (range 33-67) and median ECOG PS of 1 (range 0-2). A total of 171 cycles were given with a median number of cycles of 4 (range 1-6). There were 0 CR,9 PR,11 SD and 13 PD (response rate 21%). Grade 3-4 hematologic toxicities were: anemia in 33%,neutropenia in 22% and thrombocytopenia in 5%. Non-hematologic toxicity was generally mild. No cases of febrile neutropenia or treatment-related death were noted. The median survival was 10.8 mo (range 8.4-13 mo) and progression free survival was 8.5 mo. One-year survival rate was 40%. CONCLUSION: Our results indicate that the combination of gemcitabine and cisplatin had consistent efficacy in patients with unresectable or metastatic cholangiocarcinoma.
AIM: To study the activity of gemcitabine and cisplatin in a cohort of patients with inoperable or metastatic cholangiocarcinoma. METHODS: Chemotherapy-naive patients with pathologically proven cholangiocarcinoma, receiving treatment that consisted of gemcitabine at 1250 mg / m2 in a 30-min infusion on dl and 8, and cisplatin at 75 mg / m2 at every 21-d cycle, were retrospectively analyzed. RESULTS: From June 2003 to December 2005, 42 patients were evaluated. Twelve patients (28%) had unresectable disease and 30 %) had metastatic disease. There were 28 males and 14 females with a median age of 51 years (range 33-67) and median ECOG PS of 1 (range 0-2). A total of 171 cycles were given with a median number There were 0 CR, 9 PR, 11 SD and 13 PD (response rate 21%). Grade 3-4 hematologic toxicities were: anemia in 33%, neutropenia in 22% and thrombocytopenia in 5%. Non-hematologic toxicity was generally mild. No cases of febrile neutropenia or treatment-related death The median survival was 10.8 months (range 8.4-13 months) and progression free survival was 8.5 months. One-year survival rate was 40%. CONCLUSION: Our results indicate that the combination of gemcitabine and cisplatin had consistent efficacy in patients with unresectable or metastatic cholangiocarcinoma.