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天然免疫能够被迅速启动来抵御入侵的微生物,是机体防御病原微生物感染的第一道防线。外来微生物通过作用于模式识别受体(PRR)激活天然免疫反应,激活核因子κB(NF-κB)通路并产生1型干扰素。自噬通过降解细胞内细胞自身物质或胞内病原体为机体提供防御,并且能在多种水平下调节PRR启动的天然免疫反应。PRR与自噬之间可以相互调节,主要包括Toll/白细胞介素1受体(TIR)与自噬、视黄酸诱导基因1样受体(RLR)与自噬、炎症小体与自噬、DNA感受器与自噬之间的相互作用。
Natural immunity can be quickly activated to resist invasion of microorganisms, the body’s defense against pathogenic microorganisms is the first line of defense. Foreign microorganisms activate the innate immune response by acting on the pattern recognition receptor (PRR), activating the nuclear factor-κB (NF-κB) pathway and producing type 1 interferons. Autophagy provides defense to the body by degrading cells’ own substances or intracellular pathogens and can modulate PRR-initiated innate immune responses at various levels. PRR and autophagy can regulate each other, including Toll / interleukin 1 receptor (TIR) and autophagy, retinoic acid induced 1 receptor (RLR) and autophagy, inflammasome and autophagy, Interaction between DNA receptors and autophagy.