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丙型肝炎病毒(HCV)是输血相关性肝炎最常见的病原,因此骨髓移植(BMT)患者为HCV感染的高危对象。目前,关于HCV感染对BMT患者的远期影响了解较少,该研究旨在评价HCV感染对异基因BMT后近、远期发病率的影响。 病人与方法选择1978～1991年间进行BMT,在BMT后无病生存至少2年,且保持随访者,共161例。对随访者常规做肝功能检查,有临床指征时做肝活检。HCV抗体先用第二代酶免疫测定(EIA)筛查,后用4-抗原重组免疫印迹法或HCV-EIA补充试验检测,HCV-RNA用聚合酶链反应(PCR)检测。肝功能轻、中、重度损害的诊断标准分别为血清丙氨酸转氨酶(s-
Hepatitis C virus (HCV) is the most common cause of transfusion-related hepatitis and therefore patients with bone marrow transplant (BMT) are at high risk for HCV infection. At present, little is known about the long-term impact of HCV infection on patients with BMT. The aim of this study was to evaluate the effect of HCV infection on the near-term and long-term morbidity of allogeneic BMT. Patients and Methods Patients who underwent BMT between 1978 and 1991 had a disease-free survival of at least 2 years after BMT and were followed up for a total of 161 patients. Follow-up routine liver function tests, liver biopsy when there are clinical indications. HCV antibodies were screened by a second-generation enzyme immunoassay (EIA) followed by 4-antigen recombinant immunoblotting or HCV-EIA supplementation and HCV-RNA by polymerase chain reaction (PCR). Diagnostic criteria of mild, moderate and severe liver function were serum alanine aminotransferase (s-