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目的 探讨改进抗疟药包装提高间日疟病人服药的依从率。方法 按我国推行治疗间日疟的氯喹合并伯喹８ 日疗法的剂量和疗程，制成小盒包装。实验组使用新包装；传统用纸包或纸袋发药为对照组。采用问卷调查和测定病人血清中苯巴比妥标记物水平与剂量比率，确定新包装与传统纸包或纸袋包药病人完成全程足量的服药率。结果 新包装实验组完成全程足量服药率为９７１％ ；纸包或纸袋对照组完成全程足量服药率为８０５％ ，前者服药的依从率高于后者，两组之间差别非常显著（ Ｐ＜ ００１）。新包装药的３ 天和８ 天疗程依从率没有差别；传统纸包或纸袋分发药的８ 天疗程依从率显著低于３ 天疗程（ Ｐ＜ ００５）。结论 新包装抗疟药病人全程足量的服药依从率优于传统用纸包或纸袋包药的方法。
Objective To explore how to improve the packaging of antimalarial drugs to improve the compliance rate of patients taking vivax malaria. Methods According to our country to promote the treatment of vivax chloroquine combined with primaquine 8th dose and course of treatment, made of small box packaging. The experimental group used the new package; the traditional paper bag or paper bag as the control group. Using questionnaires and determination of the patient’s serum phenobarbital marker level and dose ratio to determine the new packaging and traditional paper bag or paper bag patients to complete the full amount of medication rate. Results In the new packaging experiment group, the full dosage rate was 971%, while the complete medication rate in the paper bag or paper bag control group was 805%. The former’s compliance rate was higher than the latter, and the differences between the two groups Very significant (P <001). There was no difference between the 3-day and 8-day medication adherence rates of the new packs. The 8-day medication adherence rate of the traditional paper packs or paper bag dispensers was significantly lower than that of the 3-day courses (P <005). Conclusions The full compliance rate of patients taking new antimalarial drug is better than that of traditional paper bag or paper bag.