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化学名 (±)-4-(4-氯苄基)-2-(六氢-1-甲基-1 H-氮杂(?)基-4)1(2 H)酞嗪酮盐酸盐结构式药效分类抗过敏药开发单位 (日)卫材公司上市厂商 (日)卫材公司1986年6月药理本品对引起变态反应的白三烯和组胺等化学介质的产生和释放具有抑制作用和直接的拮抗作用,可抑制实验性哮喘和鼻炎。其抑制产生、游离作用被认为是由于抑制脂氧酶活性,抑制钙流入,增加cAMP的水平以及膜稳定性等所致。①白三烯是变态反应疾病的重要诱因,本品强烈抑制人嗜中性白细胞产生白三烯,并抑制其平滑肌收缩作用。而且,小剂量口服时抑制白三烯参与的豚鼠实验性哮喘。②本品显著抑制组胺从人、家兔、豚鼠以及大鼠的嗜碱性白细胞和肥大
Chemical Name (±) -4- (4-Chlorobenzyl) -2- (hexahydro-1 -methyl- 1 H -azepin-4) 1 (2H) phthalazinone hydrochloride Structural Pharmacodynamic Category Anti-allergic drug development unit (Japan) Eisai company listed companies (Japan) Eisai company June 1986 Pharmacology This product is allergic to leukotriene and histamine and other chemical mediators have inhibited the production and release Role and direct antagonism, can inhibit experimental asthma and rhinitis. Its production is inhibited. The free-radical effect is thought to be due to the inhibition of the activity of the lipoxygenase, the inhibition of calcium influx, the increase of the level of cAMP and the stability of the membrane. ① leukotrienes is an important cause of allergic diseases, this product strongly inhibits the production of human neutrophils leukotriene and inhibit the smooth muscle contraction. Moreover, small doses of oral administration inhibit leukotriene in guinea pig experimental asthma. ② This product significantly inhibits the histamine from human, rabbit, guinea pig and rat basophils and hypertrophy