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目的 :比较普罗布考和他汀类药物对冠心病合并高胆固醇血症患者的疗效。方法 :113例高胆固醇血症患者分为普罗布考组和他汀类降脂药物组。比较用药前和 1年后两组患者血脂、氧化修饰低密度脂蛋白 (OX LDL)、超氧化物歧化酶 (SOD)、丙二醛 (MDA)及心绞痛发作的变化。结果 :两组均明显降低血清中总胆固醇 (TC)和低密度脂蛋白胆固醇 (LDL C)水平 ,但普罗布考对降低OX LDL和MDA及升高SOD有显著效果 ,同时明显减少心绞痛发作次数 ,提高患者运动耐量。结论 :普罗布考为一安全有效的降血脂及减少心绞痛发作的药物
OBJECTIVE: To compare the efficacy of probucol and statins in patients with coronary heart disease complicated with hypercholesterolemia. Methods: 113 cases of hypercholesterolemia were divided into probucol group and statins lipid-lowering drug group. The changes of blood lipids, oxidized low density lipoprotein (OX LDL), superoxide dismutase (SOD), malondialdehyde (MDA) and the incidence of angina pectoris were compared between two groups before and one year after treatment. Results: Serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL C) levels were significantly decreased in both groups, but probucol significantly reduced OX LDL, MDA and SOD, and significantly reduced the number of angina attacks , Improve patient exercise tolerance. Conclusion: Probucol is a safe and effective drug that reduces blood fat and reduces the incidence of angina pectoris