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胰岛素依赖性糖尿病(IDDM)是一种遗传特征,不易以现行遗传模型进行解释的疾病。对人群和家系中进行HLA系统的研究可为与HLA联结的糖尿病基因提供证据。已经发现IDDM的遗传标志在不同种族人群中是不同的。如高加索IDDM患者中以HLA B_8、BW_(15)和/或B_(18)出现率高,但在日本则为HLA BW_(22)～J_1(BW_(54)),为一种特异的亚型,而在北印度则为HLA BW_(21)。本文报告是确定居住在新加坡中国儿童中的HLA抗原与IDDM的关系。HLA分型采用美国国立卫生研究所(NIH)淋巴细胞毒微量法,共观察12例无亲属关系的IDDM的中国儿童,其中女性3例、男性9例,发病年龄从2～46岁不等,并
Insulin-dependent diabetes mellitus (IDDM) is a genetic disorder that is not easily explained by current genetic models. Research on HLA systems in populations and pedigrees provides evidence of HLA-linked diabetes genes. It has been found that genetic markers of IDDM are different among different ethnic groups. Such as HLA B_8, BW_ (15) and / or B_ (18) in Caucasians with IDDM, but HLA-B_22 ~ J_1 (BW_ (54)) in Japan is a specific subtype , While in North India it is HLA BW_ (21). This paper reports the determination of the association of HLA antigens with IDDM in Chinese children living in Singapore. HLA typing using the National Institutes of Health (NIH) lymphocytotoxicity trace method, a total of 12 Chinese children without IDDM were observed, including 3 females and 9 males, the age of onset ranging from 2 to 46 years old, and