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目的 :对比研究应用氯沙坦和福辛普利逆转原发性高血压 (EH)伴左心室肥厚 (LVH)的作用。方法 :将 12 0例EHLVH患者随机分为氯沙坦组 (n =6 0 )和福辛普利组 (n =6 0 ) ,于服药前及服药 6个月后分别测定血压、室间隔厚度 (IVST)、左心室后壁厚度 (PWT)、左心室舒张末期直径 (LVDd)、左心室重量指数 (LVMI)、左心室射血分数 (LVEF)、心排血量 (CO)和A/E峰值。结果 :两组患者经治疗后血压、IVST、PWT、LVDd、LV MI、A/E峰值均显著降低 (均P <0 .0 1) ,而LVEF、CO无显著变化 (P >0 .0 5 )。结论 :氯沙坦与福辛普利均能逆转LVH ,明显改善左心室舒张功能
AIM: To compare the effects of losartan and fosinopril on reversing essential hypertension (EH) with left ventricular hypertrophy (LVH). Methods: A total of 120 EHLVH patients were randomly divided into losartan group (n = 60) and fosinopril group (n = 60). Blood pressure, interventricular septum thickness (IVST), left ventricular posterior wall thickness (PWT), left ventricular end diastolic diameter (LVDd), left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), cardiac output (CO) and A / E Peak. Results: After treatment, the peak values of IVST, PWT, LVDd, LVMI and A / E were significantly decreased in both groups (all P <0.01), while there was no significant change in LVEF and CO (P> 0.05) ). Conclusion: Losartan and fosinopril can both reverse LVH and significantly improve left ventricular diastolic function