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目的:了解北京市顺义区在校学生接种甲型H1N1流感疫苗前后的抗体水平,为卫生部门制定防控措施提供依据。方法:随机选取4个乡街的学生,监测接种甲型H1N1流感疫苗前后的抗体水平。结果:46份免疫前血清标本中甲型H1N1流感抗体水平阳性率58.70%(27/46),与北京市人群甲型H1N1流感抗体水平检测结果有差别(P<0.05),抗体几何平均滴度倒数(GMRT)41.2。免疫后抗体阳性率89.1%(41/46),抗体阳转率78.26%(36/46)。46对血清抗体滴度总体呈9倍增高,免疫后GMRT为380.55。不同性别学生之间免疫后抗体水平阳性率无差别(χ2=0.00,P>0.05),小学组和中学组之间抗体水平阳转率无差别(χ2=0.049,P>0.05)。结论:顺义区在校学生可能有一半以上曾感染甲型H1N1流感,感染与性别无关,与年龄有关,中学组感染率高于小学组。甲型H1N1流感流行期间接种疫苗是控制学校疫情的必要手段。
Objective: To understand the antibody levels of school students in Shunyi District of Beijing before and after the inoculation of influenza A (H1N1) influenza vaccine and provide basis for the prevention and control measures of the health department. Methods: Four township students were randomly selected to monitor the antibody levels before and after the influenza A (H1N1) vaccination. Results: The positive rate of influenza A (H1N1) antibody in 46 serum samples was 58.70% (27/46) before immunization, which was different from that in Beijing (P <0.05). The geometric mean antibody titer Countdown (GMRT) 41.2. After immunization, the positive rate of antibody was 89.1% (41/46) and the positive rate of antibody was 78.26% (36/46). 46 pairs of serum antibody titer overall increased 9-fold, GMRT after immunization was 380.55. There was no difference in antibody positive rate among different sexes (χ2 = 0.00, P> 0.05). There was no difference in positive rate of antibody between primary and secondary school (χ2 = 0.049, P> 0.05). Conclusion: More than half of the students in Shunyi District may have been infected with Influenza A (H1N1). The infection has nothing to do with gender and age, and the infection rate of middle school students is higher than that of primary school students. Vaccination during the influenza A (H1N1) epidemic is a necessary means of controlling school outbreaks.