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葡萄糖与盐酸普魯卡因混合注射液系作靜脉輸入强化麻醉剂用于外科手术,亦作靜脉封閉疗法用药用于各种过敏性疾患如过敏性紫癜、荨麻疹等。其中葡萄糖的浓度多为5%;普魯卡因的浓度为0.25%,也有用0.5%及1%者。該制剂配制后,往往产生变色而不能使用,因此,文献介紹将此两种药物分別配制,临用时进行混合。但这种配制法,不仅手續繁瑣,且产品毒性亦較大。为了配制好該制剂,我們对影响注射液呈色的因素进行了研究,找到了降低呈色程度的条件,并对呈色反应的机制作了初步探討。
Glucose and procaine hydrochloride injection for intravenous infusion of intensive anesthesia for surgery, also used for intravenous closed therapy medication for a variety of allergic disorders such as Henoch-Schonlein purpura, urticaria and so on. Among them, the concentration of glucose is mostly 5%; the concentration of procaine is 0.25%, which is also useful for 0.5% and 1%. The preparation of the preparation, often produce discoloration and can not be used, therefore, the literature describes the preparation of these two drugs separately, when used for mixing. However, this preparation method, not only cumbersome procedures, and product toxicity is also greater. In order to prepare the preparation, we studied the factors that affect the color of the injection, found the conditions to reduce the color degree, and discussed the mechanism of the color reaction.