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按２４ｈ尿白蛋白排泄量（ＵＡＥ）将５８例非胰岛素依赖型糖尿病患者分为尿白蛋白正常组（Ⅰ组）和微量尿白蛋白组（Ⅱ组），比较两组血脂、血压、冠心病及视网膜微血管病变的差异。结果示：Ⅱ组载脂蛋白Ａ１（ＡｐｏＡ１），载脂蛋白Ａ１与载脂蛋白Ｂ１００的比值（ＡｐｏＡ２／ＡｐｏＢ１００）较Ⅰ组降低（Ｐ＜０．０５），冠心病、视网膜微血管病变的发生率明显增高（Ｐ＜０．０５）。相关性分析示ＡｐｏＡ１，ＡｐｏＡ１／ＡｐｏＢ１００值和高密度脂蛋白（ＨＤＬ）与２４ｈＵＡＥ呈负相关；收缩血压与２４ｈＵＡＥ呈正相关。提示微量白蛋白尿与ＮＩＤＤＭ脂质代谢紊乱及合并血管病变有关。
Fifty-eight patients with non-insulin-dependent diabetes mellitus were divided into normal group (group Ⅰ) and microalbuminuria group (group Ⅱ) according to urinary albumin excretion (24h). The levels of blood lipid, blood pressure, coronary heart disease And retinal microangiopathy differences. The results showed that the ratio of ApoA1, apolipoprotein A1 to apolipoprotein B100 in group Ⅱ was lower than that in group Ⅰ (P <0.05), and the incidence of coronary heart disease and retinal microangiopathy Was significantly higher (P <0.05). Correlation analysis showed that ApoA1, ApoA1 / ApoB100 values and high density lipoprotein (HDL) negative correlation with 24hUAE; systolic blood pressure and 24hUAE was positively correlated. Tip microalbuminuria and NIDDM lipid metabolism disorders and associated vascular disease.