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Ｔ细胞在ＴＣＲ及其刺激分子如ＣＤ2 8的共同作用下被活化。ＣＴＬＡ 4和ＣＤ2 8结合相同的配体即ＣＤ80 (Ｂ7-1)和ＣＤ86 (Ｂ7-2 )。与ＣＤ2 8不同的是 ,ＣＴＬＡ 4在静止的Ｔ细胞不表达 ,Ｔ细胞活化后表达增加并对Ｔ细胞应答有抑制作用。最近还发现在小鼠体内抑制ＣＴＬＡ
T cells are activated by TCR and its stimulatory molecules such as CD28. CTLA4 and CD28 bind the same ligands CD80 (B7-1) and CD86 (B7-2). Unlike CD28, CTLA4 is not expressed in resting T cells, but is increased after T cell activation and has an inhibitory effect on T cell responses. It has also recently been found that CTLA is inhibited in mice