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前列腺癌导致骨质疏松加速,骨折发生的危险性增加。口服雌激素治疗是雄激素抑制治疗的最初方法,但由于心血管和血栓形成的危险性及其肝毒性,其使用受到限制。研究表明,毒性产生的重要因素是给药途径。作者提出经皮雌二醇治疗显示有效的激素和肿瘤反应,同时可以减少这些危险性,是有效的雄激素剥夺治疗的替代疗法。作者报告了前列腺癌患者使用经皮雌二醇治疗对骨密度的影响。20例新诊断的局部晚期前列腺癌患者应用经皮雌二醇贴片治疗,每隔6个月应用双能量吸光光度法测量腰椎和上段股骨的骨密度,同时行CT和骨扫描检查。结果显示随时间延
Prostate cancer leads to accelerated osteoporosis, the risk of fracture increases. Oral estrogen therapy is the first method of androgen depressant therapy, but its use is limited due to its cardiovascular and thrombotic risks and its hepatotoxicity. Studies have shown that toxicity is an important factor in the route of administration. The authors suggest that transdermal estradiol therapy shows potent hormonal and tumor responses while reducing these risks and is an effective alternative to androgen deprivation therapy. The authors report the effect of transdermal estradiol treatment on BMD in prostate cancer patients. Twenty patients with newly diagnosed locally advanced prostate cancer were treated with transdermal estradiol patch. Bone mineral density of the lumbar spine and upper femur was measured by dual energy absorptiometry every 6 months. CT and bone scan were performed simultaneously. The results show that with time delay