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近年来对成人呼吸窘迫综合征(以下简称ARDS)致病机理的研究进展很快。Esbenshade等用大肠杆菌内毒素灌注绵羊,获得与人类ARDS 近似的急性呼吸衰竭模型。11只绵羊中有8只发生呼吸衰竭,出现明显的低氧血症,肺动脉压升高,肺淋巴流增加,其中6只胸片显示进行性肺水肿。Brigham 等在内毒素血症的绵羊体中发现,开始阶段肺动脉压明显增高,当肺血管压力降至基线后,
In recent years, the research on the pathogenesis of adult respiratory distress syndrome (hereinafter referred to as ARDS) is progressing rapidly. Esbenshade et al. Infected sheep with E. coli endotoxin to obtain a model of acute respiratory failure similar to human ARDS. Eight of the 11 sheep developed respiratory failure with significant hypoxemia, elevated pulmonary arterial pressure, and increased pulmonary lymphatic flow, with six of the chest radiographs showing progressive pulmonary edema. Brigham et al found that endotoxemia in the sheep body, the initial stage of pulmonary hypertension was significantly increased, when the pulmonary vascular pressure dropped to baseline,