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目的:研究中华雪胆化学成分。方法:应用色谱技术进行分离和纯化,采用UV,IR,MS,NMR等波谱技术鉴定结构。结果:从中华雪胆中分到8个三萜类化合物,分别为23,24-二氢葫芦素B(1),23,24-二氢葫芦素F-25-乙酸酯(2),葫芦素F(3),3-O-(6’-乙酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-α-L-吡喃阿拉伯糖苷(4),齐墩果酸-3-O-(6’-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-3)-α-L-吡喃阿拉伯糖苷(5),齐墩果酸-28-O-β-D-吡喃葡萄糖基(1-6)-β-D-吡喃葡萄糖苷(6),3-O-(6’-甲酯)-β-D-吡喃葡萄糖醛酸基-齐墩果酸-28-O-β-D-吡喃葡萄糖基-(1-6)-β-D-吡喃葡萄糖苷(7),3-O-(6’-甲酯)-β-D-吡喃葡萄糖醛酸基-(1-2)-β-D-吡喃葡萄糖基-齐墩果酸-28-O-β-D-吡喃葡萄糖苷(8)。结论:除化合物2外,其余化合物均是首次从中华雪胆中分离得到。
Objective: To study the chemical constituents of Chinese snakebite. Methods: Chromatography was used to separate and purify the structure. The structures were identified by UV, IR, MS and NMR techniques. Results: Eight Chinese triterpene compounds were isolated from Chinese snowshoes, which were 23,24-dihydro-cucurbitacin B (1), 23,24-dihydro-cucurbitacin F- Cucurbitacin F (3), 3-O- (6’-ethyl ester) -β-D-glucopyranonoyl-oleanolic acid -28-O-α-L-arabinopyranoside , Oleanolic acid 3-O- (6’-methyl ester) -β-D-glucopyranosyl- (1-3) -α-L-arabinopyranoside (5) Acid-28-O-β-D-glucopyranosyl (1-6) -β-D-glucopyranoside (6) Glucuronyl-oleanolic acid -28-O-β-D-glucopyranosyl- (1-6) -β-D-glucopyranoside (7) Β-D-glucopyranonyl- (1-2) -β-D-glucopyranosyl-oleanolic acid-28-O-β-D-glucopyranoside (8). Conclusion: Except for compound 2, all the other compounds were isolated from Chinese snake broom for the first time.