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长期输入为人体治疗用量20倍的争光霉素,没有引起大鼠正常的食管上皮细胞的形态改变,但对甲基苄基亚硝胺引起的增生及癌前病变(乳头状瘤)具有较为明显的抑制作用。争光霉素对癌的发生也有阻断作用。争光霉素引起的食管异常上皮的病理改变,主要表现为核固缩、核周空晕、核旁空泡、核碎裂等细胞的渐进性坏死和死亡。同时还看到上皮的液化灶与灶性的增生抑制区。重要的内脏器官除发现肾变性之外,其他未见异常。争光霉素对食管上皮的增生和癌前病变选择性的抑制与破坏作用,也为食管癌的予防性治疗提供一项有用的药物。争光霉素是我国自己生产的,与博莱霉素(Bleomycin)相类似的抗菌素,在临床上已证明对鳞状上皮癌,如皮肤癌与食管癌等有疗效。为了探索争光霉素能否阻断亚硝胺诱发食管鳞状上皮的癌变,特别是对增生与癌前病变有无抑制作用,我们进行了以下的试验。
The long-term input of bleomycin, which is 20 times the therapeutic amount of humans, did not cause normal morphological changes of the esophageal epithelium in rats, but it was more obvious in the hyperplasia and precancerous lesions (papillary tumors) caused by methylbenzyl nitrosamines. The inhibitory effect. Consolomycin also has a blocking effect on the occurrence of cancer. The pathological changes of esophageal epithelium caused by bleomycin were mainly manifested by progressive necrosis and death of cells such as nuclear condensation, perimenopausal halo, paranuclear vacuoles and nuclear fragmentation. At the same time, epithelial liquefaction and focal hyperplasia were also seen. In addition to the discovery of renal degeneration, important organs were not abnormal. The inhibition and destruction of bleomycin for the proliferation and precancerous lesions of esophageal epithelium also provide a useful drug for the prophylactic treatment of esophageal cancer. Conotoxin is produced in China. Antibiotics similar to Bleomycin have been clinically proven to be effective against squamous cell carcinomas such as skin cancer and esophageal cancer. In order to explore whether or not bleomycin can block nitrosamine-induced carcinogenesis of esophageal squamous epithelium, especially whether it has inhibitory effects on hyperplasia and precancerous lesions, we conducted the following tests.