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目的：探讨鼻咽鳞癌组织分化与ｃ－ｆｏｓ癌基因的关系。方法：采用免疫组化ＡＢＣ法和图象分析技术检测１２５例鼻咽癌的ｃ－ｆｏｓ癌基因表达产物及其阳性胞核面积。结果：非角化性鳞癌ｃ－ｆｏｓ癌基因阳性率（４４．４％）高于角化性鳞癌（１７．７％），前者中低分化鳞癌与未分化癌之间的ｃ－ｆｏｓ阳性率差异没有显著性，而核面积明显增大的未分化泡状癌细胞核未见阳性表达。结论：鼻咽鳞癌细胞的分化程度与ｃ－ｆｏｓ癌基因的表达密切相关。
Objective: To investigate the relationship between the differentiation of nasopharyngeal squamous cell carcinoma and c-fos oncogene. Methods: Immunohistochemical ABC method and image analysis technique were used to detect the expression of c-fos oncogene and its positive nucleus area in 125 cases of nasopharyngeal carcinoma. Results: The positive rate of c-fos oncogene in non-keratinizing squamous cell carcinomas (44.4%) was higher than that in keratinizing squamous cell carcinomas (17.7%). The former poorly differentiated squamous cell carcinoma and undifferentiated squamous cell carcinoma c- fos positive rate difference was not significant, while the nuclear area was significantly increased in undifferentiated vesicular cancer cells showed no positive expression. Conclusion: The degree of differentiation of nasopharyngeal squamous cell carcinoma is closely related to the expression of c-fos oncogene.