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糖尿病性微血管病变是糖尿病并发器官损害的特异性病理基础,见于肾脏、眼底以及皮肤、肌肉、胃肠等器官组织,但尚未见骨髓微血管病变的研究报道。为此,作者对118例显性糖尿病患者的髂嵴活检,进行组织学的和组织形态测量学的研究,并与临床指标相对照。研究对象和方法118例中男54、女64例。小于30岁者10例,30～60岁者40例,60岁以上68例。病程10年以下者78例,10年以上者37例,3例不详。另有62例正常人作对照。活检采自右侧髂嵴(15～20×4mm圆柱),应用5种染色法,即Giemsa、Gomori、Ladewig、PAS、Turnbull。其中3例作免疫组织学的检查,系用豚鼠对小牛胶元质的抗体Ⅰ、Ⅱ、Ⅲ型。
Diabetic microangiopathy is a specific pathological basis of diabetic organ damage, found in the kidneys, fundus and skin, muscle, gastrointestinal and other organ tissue, but has not yet been reported in the study of bone marrow microvascular disease. To this end, the authors of 118 patients with dominant diabetes iliac crest biopsy, histological and histomorphometric studies, and with clinical indicators. Subjects and methods 118 cases of male 54, female 64 cases. 10 patients less than 30 years old, 30 to 60 years old in 40 cases, 68 years old 68 cases. 78 cases of disease duration of less than 10 years, 37 cases of more than 10 years, 3 cases unknown. Another 62 normal controls. Biopsy taken from the right iliac crest (15 ~ 20 × 4mm cylinder), the application of five kinds of staining methods, namely Giemsa, Gomori, Ladewig, PAS, Turnbull. Three of them were examined by immunohistology, using guinea pig antibodies to type I, II, and III of calf glue.