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特发性血小板减少性紫癜(ITP)患者的血清中存在抗血小板自身抗体,循环血小板减少而骨髓巨核细胞正常或增高。曾有资料提示,患者的脾脏对产生自身抗体起一定作用。但对ITP的细胞免疫功能所知甚少。作者测定了23例ITP成人患者的T细胞亚群。其中15例在诊断时或停止治疗至少3周后测定。15例中4例作了脾切除,T细胞亚群分别在切脾前和切脾后10～15天进行。另8例在测定时巳切脾14～49月。其中5
Anti-platelet autoantibodies exist in the serum of patients with idiopathic thrombocytopenic purpura (ITP), with circulating platelets reduced and bone marrow megakaryocytes normal or elevated. There have been data suggest that the patient’s spleen to produce autoantibodies play a role. Little is known about the cellular immune function of ITP. The authors measured T cell subsets in 23 ITP adult patients. Of these, 15 were measured at diagnosis or at least 3 weeks after cessation of treatment. Four of the 15 patients underwent splenectomy. The T cell subsets were performed 10 ~ 15 days before splenectomy and after splenectomy respectively. The other 8 cases had splenectomy in the determination of 14 to 49 months. Five of them