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已知再生障碍性贫血(简称 AA)由造血干细胞受损及/或骨髓微环境障碍所致。Ascensao 等(1976)发现 AA 患者存在单核细胞群抑制物,于体外能抑制正常人骨髓细胞的集落形成。Hoffman 等(1977)报道 AA 中有红系集落形成的抑制物。Jea-nnet 等观察到 AA 在骨髓移植前用免疫抑制剂治
It is known that aplastic anemia (AA for short) is impaired by hematopoietic stem cells and / or impaired bone marrow microenvironment. Ascensao et al. (1976) found that patients with AA present with a monocyte population inhibitor that inhibits colony formation in normal human bone marrow cells in vitro. Hoffman et al. (1977) reported inhibitors of erythroid colony formation in AA. Jea-nnet et al observed that AA was immunosuppressed prior to bone marrow transplantation