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为探讨腋淋巴结阴性乳腺癌(ANNBC)中血管生成及nm23-H_1基因的表达与预后的关系,筛选80例病理类型为浸润性导管癌的ANNBC患者进行随访,中位随访时间为65.0个月。应用免疫组织化学SABC法检测原发肿瘤标本中的微血管密度(MVD)及nm23-H_1基因表达情况,结合临床随访资料进行生存分析。结果显示MVD、nm23-H_1均可作为估计预后的因素,nm23-H_1与MVD联合检测对预后价值更大,对高MVD者给予有针对性的抗血管生成治疗或基因治疗可能有更重要的意义。
To investigate the relationship between angiogenesis and nm23-H_1 gene expression and prognosis in axillary lymph node-negative breast cancer (ANNBC), 80 consecutive ANNBC patients with pathological type of invasive ductal carcinoma were screened for a median follow-up of 65.0 months. Immunohistochemical SABC method was used to detect the microvessel density (MVD) and nm23-H 1 gene expression in the primary tumor specimens. Survival analysis was performed with clinical follow-up data. The results showed that both MVD and nm23-H_1 could be used as prognostic factors. The combined detection of nm23-H_1 and MVD may have more prognostic value, and may be more important for targeted therapy of anti-angiogenesis or gene therapy in patients with high MVD .