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目的探讨急性脑出血患者血清甲状腺激素水平及其临床意义。方法根据脑出血量多少、神经功能缺损程度及治疗2周后的疗效,将98例急性脑出血患者分为:脑出血量≤30ml为A组、>30ml为B组;神经功能缺损程度轻型的为C组、中型的为D组、重型的为E组;疗效为显效的为F组、有效的为G组、无效的为H组。选择40例健康者作对照。采用电化学发光法检测急性脑出血患者和健康对照者血清中T3、T4、FT3、FT4、TSH水平。结果急性脑出血患者A、B、C、D、E、G和H组与健康对照组,B组与A组,D、E组与C组,G、H组与F组之间,甲状腺激素水平差异均有统计学意义(P<0.05),T4、FT4、TSH水平升高,而T3、FT3水平下降。而疗效为显效的F组与健康对照组比较,甲状腺激素水平差异无统计学意义(P>0.05)。结论急性脑出血患者T4、FT4、TSH水平升高和T3、FT3水平下降与病情的严重程度及预后密切相关。
Objective To investigate the serum thyroid hormone level in patients with acute cerebral hemorrhage and its clinical significance. Methods According to the amount of cerebral hemorrhage, the degree of neurological deficit and the curative effect after 2 weeks of treatment, 98 patients with acute intracerebral hemorrhage were divided into three groups: group A with a blood loss ≤ 30ml, group B with> 30ml; group B with mild neurological deficits For the C group, medium for the D group, heavy for the E group; effective for the F group, effective for the G group, invalid for the H group. Forty healthy people were selected as control. The serum levels of T3, T4, FT3, FT4 and TSH in patients with acute cerebral hemorrhage and healthy controls were detected by electrochemiluminescence. Results A, B, C, D, E, G and H in patients with acute intracerebral hemorrhage were significantly different from those in healthy control group, B group and A group, D and E group and C group, G, H group and F group, thyroid hormone (P <0.05). The levels of T4, FT4 and TSH increased, while the levels of T3 and FT3 decreased. However, there was no significant difference in thyroid hormone levels between the F group and the healthy control group (P> 0.05). Conclusion The elevated levels of T4, FT4 and TSH and the decrease of T3 and FT3 levels in patients with acute cerebral hemorrhage are closely related to the severity and prognosis of the patients.