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目的：单用依那普利（Ｅｎａ）与联用硝苯地平控释片（ｎｉｆ－ＣＲ），治疗老年原发性高血压疗效比较。方法：单用Ｅｎａ组３６例（男性２４例，女性１２例，年龄６７±ｓ１３ａ），剂量５～２０ｍｇ，ｐｏ，ｂｉｄ，平均剂量为２４±８ｍｇ／ｄ；联用组５０例（男性３２例，女性１８例，年龄６８±５ａ）。采用Ｅｎａ片２．５～１０ｍｇ，ｐｏ，ｂｉｄ，平均剂量为１２±４ｍｇ，加用Ｎｉｆ－ＣＲ片３０ｍｇ，ｐｏ，ｑｄ。疗程均４ｗｋ．结果：单用组与联用组降压显效率分别为４２％与７８％，总有效率分别为７２％与９４％，组间比较Ｐ＜０．０１。２组不良反应轻微。结论：联用组疗效优于单用组。
OBJECTIVE: To compare the efficacy of Ena alone with nif-CR in the treatment of senile essential hypertension. Methods: Thirty-six patients (24 males and 12 females, age 67 ± s13a) were enrolled in Ena group. The dosage was 5-20 mg, po, bid, the average dose was 24 ± 8 mg / d. , 18 females, age 68 ± 5a). Ena tablets 2.5 ~ 10mg, po, bid, the average dose of 12 ± 4mg, plus Nif-CR tablets 30mg, po, qd. Treatment are 4wk. Results: The effective rates of lowering blood pressure were 42% and 78% respectively in group A and group B, and the total effective rates were 72% and 94% respectively. There was a slight adverse reaction in group P and group P 0.01. Conclusion: Combination group is better than single use group.