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目的研究分析炎症因子在老年2型糖尿病患者认知功能障碍中的作用。方法选取老年2型糖尿病患者42例为研究组,同期非糖尿病健康老年受试者30例为对照组,测量受试者相关炎症因子水平,并对受试者进行认知评分,分析2组各项指标。结果 2组受试者年龄、血压、血脂以及肝肾功能相关指标比较无显著差异(P>0.05)。研究组受试者MMES评分、CRP、s ICAM-1、s VCAM-1、IL-1β以及TNF-α均与对照组有显著差异(P<0.05)。结论炎症因子可对老年2型糖尿病患者大脑中枢功能造成影响,引起患者认知功能障碍。
Objective To study the role of inflammatory cytokines in cognitive impairment in elderly type 2 diabetic patients. Methods Forty-two elderly patients with type 2 diabetes mellitus (T2DM) were selected as the study group, and 30 healthy non-diabetic elderly subjects were selected as the control group. The levels of inflammatory cytokines in the subjects were measured, and the cognitive score of the subjects was calculated. Item indicator. Results There was no significant difference in age, blood pressure, blood lipid, liver and kidney function between the two groups (P> 0.05). There were significant differences in MMES scores, CRP, s ICAM-1, s VCAM-1, IL-1β and TNF-α between the two groups (P <0.05). Conclusion Inflammatory cytokines may affect the brain function of the elderly patients with type 2 diabetes and cause cognitive dysfunction in patients.