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过去20年间,对溶血性贫血与6-磷酸葡萄糖脱氢酶、丙酮酸激酶、磷酸葡萄糖异构酶、嘧啶-5＇-核苷酸酶和其他一些酶缺乏之间的明确关系的认识,大大地推进了我们对溶血性疾病的病因和红细胞代谢的某些基本情况的了解。虽然某些遗传性非球形红细胞溶血性贫血病例的病因业经正确地鉴定,而其他病例的病因则仍使红细胞生化研究者困惑不解,这些病例很自然地被许多研究室以大组的红细胞酶分析加以研究。当发现了酶缺乏时,往往推测其与慢性溶血之间存在因果关系。谷胱甘肽还原酶即是一适例。许多文章和综述,包括最近发表的,已将此酶缺乏列为慢性溶血性贫血的病因之一。然而,我们现已认识到,绝大多数病例的谷胱甘肽还原酶部分缺
Over the past two decades, a clear understanding of the clear relationship between hemolytic anemia and 6-phosphoglucose dehydrogenase, pyruvate kinase, phosphoglucose isomerase, pyrimidine-5’-nucleotidase, and other enzyme deficits has been significantly greater In advance of our understanding of the etiology of hemolytic disease and some basic conditions of erythrocyte metabolism. Although the etiology of some hereditary non-spherical red blood cell hemolytic anemia has been correctly identified, and the etiology of other cases remains puzzling the chemobiology of erythrocytes, these cases are naturally followed by many studies with large groups of erythrocytic enzymes Analysis to study. When enzyme deficiency is found, it is often hypothesized that there is a causal relationship between it and chronic hemolysis. Glutathione reductase is an example. Many articles and reviews, including the recently published one, have listed this enzyme as one of the causes of chronic hemolytic anemia. However, we now recognize that glutathione reductase is missing in most cases