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用全胚胎培养并结合病理检查探讨了不同浓度砷对离体胚胎组织器官的影响。镜下结果表明，砷对脑部、神经管、心脏、卵黄囊、肢芽、体节等组织器官的形态分化均有明显抑制作用，呈现剂量反应关系。０．５μｇ／ｍｌ砷仅对脑部有轻度损害，可见内皮层和边缘层细胞脱落，说明脑是砷毒作用的一个敏感靶器官。砷≥１．０μｇ／ｍｌ时，脑和神经管的室管膜层细胞数量减少、排列紊乱、变性坏死；同时可见卵黄囊三层膜结构紊乱、微血管数量减少；心脏、肢芽等器官亦出现一定的病理改变
The effects of different concentrations of arsenic on the tissues and organs of isolated embryos were investigated by whole embryo culture and pathological examination. Microscopic results show that arsenic on the brain, neural tube, heart, yolk sac, limb buds and other tissues and organs of the morphological differentiation were significantly inhibited, showing dose-response relationship. 0.5μg / ml arsenic only mild damage to the brain, visible endocortical and marginal layer cells shedding, indicating that the brain is a sensitive target of arsenic toxicity. When arsenic ≥1.0μg / ml, the number of ependymal cells in the brain and neural tube decreased, arranged disorder, degeneration and necrosis; At the same time, the structure of the three layers of yolk sac was disordered and the number of microvessels decreased; heart, limb bud and other organs also appeared Certain pathological changes